In vitro susceptibility of Neisseria gonorrhoeae to 2-acetylpyridine thiosemicarbazones
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چکیده
منابع مشابه
In vitro susceptibility of Neisseria gonorrhoeae to nine antimicrobial agents.
The in vitro action of nine antibiotics was tested by the agar streak method against 45 gonococcal strains isolated from penicillin-therapy failures. The penicillin susceptibility range of these strains was 0.003 to 1.32 mug/ml, and the tetracycline susceptibility range was 0.125 to 2.0 mug/ml. Minimal inhibitory concentrations of minocycline and doxycycline paralleled the activity of tetracycl...
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Four hundred and forty-two isolates of Neisseria gonorrhoeae were tested by an agar dilution method for their susceptibility to penicillin, ampicillin, tetracycline, cephaloridine, and spectinomycin. Of these isolates, 295 were tested for their susceptibility to sulphamethoxazole and to trimethoprim by the same method, using Oxoid diagnostic sensitivity test agar plus 7.5% laked horse blood ins...
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Antibiotic susceptibilities were determined for 122 Neisseria gonorrheae isolates obtained from 400 sex workers in Jakarta, Indonesia, and susceptibilities to ciprofloxacin, cefuroxime, cefoxitin, cefotaxime, ceftriaxone, chloramphenicol, and spectinomycin were found. All isolates were resistant to tetracycline. A number of the isolates demonstrated decreased susceptibilities to erythromycin (M...
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Antibiotic-resistant isolates of Neisseria gonorrhoeae remain an important public health problem. Fluoroquinolones, such as ciprofloxacin, have excellent penetration into the genitourinary tract and have been shown to be highly active against N. gonorrhoeae, including penicillinase-producing strains (PPNG). However, strains with decreased susceptibility to fluoroquinolones have been reported in...
متن کاملIn vitro assessment of 2-acetylpyridine thiosemicarbazones against chloroquine-resistant Plasmodium falciparum.
A series of 2-acylpyridine thiosemicarbazones was evaluated in vitro against a chloroquine-resistant Plasmodium falciparum strain. Antimalarial activity was assessed by the inhibition of uptake of [G-3H]hypoxanthine by the parasites. Among the mono- and disubstituted derivatives tested, 13 of 17 had 50% inhibitory doses of less than 10 ng/ml. Increasing the size of the ring at N4 from four to f...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1985
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.27.4.570